Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


Currently viewing:

Administrative data

Description of key information

The following study has been submitted to address the neurotoxicity endpoint:
EFSA (2004) Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission to assess the health risks to consumers associated with exposure to organotins in foodstuffs. The EFSA Journal 1002: 1-119
As the study is secondary source it has been allocated a Klimisch score of 4.

Key value for chemical safety assessment

Additional information

The SPCFC (2004) review of organotins considered evidence of neurotoxicity and concluded that, while there is clear-cut evidence of neurotoxicity with regard to trimethyl tin, triethyltin and triphenyltin, other tri- and also di-alkyltins are less or - possibly - not neurotoxic at all. There is a lack of systematic experimental data showing NOAELs. Dibutyltin shows the same biochemical effect (decoupling of oxidative phosphorylation). With regard to risk assessment NOAELs cannot be derived from the studies. It is however clear from available studies, that any potential neurotoxicity is not the most sensitive marker of dibutyltin toxicity.

Justification for classification or non-classification