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EC number: 273-258-7 | CAS number: 68955-20-4 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol sulfuric acid sodium salt and SDA Reporting Number: 19-062-04.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are three studies regarding skin sensitisation with C16-18AS Na (CAS 68955-20-4) available.
The skin sensitizing potential of C16-18AS Na (CAS 68955-20-4, analytical purity 55%) was assessed in a Guinea Pig Maximisation Test according to OECD Guideline 406 (Kästner, 1986). In this study guinea pigs were induced by intradermal and epicutaneous application of the test item at concentrations of 0.01% (intradermal induction) and 10% (epicutaneous induction). Challenge was performed with 5% after 14 days. Water was used as vehicle. 1/20 (5%) animals treated with the test item and 0/20 animals of the control group showed a positive reaction at the 24h reading after challenge. At the second reading (48 h after challenge) no skin reactions were observed. Thus, the test item showed no significant sensitising potential within this study.
A second study on skin sensitisation with C16-18AS Na (CAS 68955-20-4) was performed as a Landsteiner test. Small amounts of a 25% aqueous solution were rubbed to the clipped skin of guinea pigs. This induction procedure was repeated in 24 h intervals for another 9 times. 14 days after the induction the animals were challenged by brushing a 1% aqueous solution of the test item onto the skin. This treatment was repeated after 24 h. The induction caused a slight redness of the treated skin in all animals, while no skin reactions were observed upon challenge. Thus, the test item showed no significant sensitising potential within this study.
The third study with C16-18AS Na (CAS 68955-20-4) assessed the skin sensitising potential on humans. Human volunteers (97) were induced with 0.25% aqueous solutions of the test item under occlusive conditions for 24 h, three times a week for a period of three weeks. The volunteers were challenged with the same concentration 14 days after the induction period on both arms. Mild erythema was observed at challenge. However no evidence of skin sensitisation was observed.
Results of the above mentioned studies show that C16-18AS Na (CAS 68955-20-4) is not a skin sensitiser. Another alkyl sulfate, i.e. sodium lauryl sulphate (C12AS Na) is recommended as an agent to induce local irritation in a method to assess skin sensitising properties of chemicals (OECD guideline 406, Guinea Pig Maximisation Test).Therefore there is a lot of experience with sodium lauryl sulfate in sensitising studies and no evidence occurred that it shows sensitising properties. Thus, skin sensitisation by members of the alkyl sulfates is generally unlikely.
Migrated from Short description of key information:
Skin sensitisation (GPMT - OECD 406): not sensitising
Justification for selection of skin sensitisation endpoint:
Reliable OECD guideline study.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
No data available for respiratory sensitisation.
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