Registration Dossier
Registration Dossier
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EC number: 273-258-7 | CAS number: 68955-20-4 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol sulfuric acid sodium salt and SDA Reporting Number: 19-062-04.
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
7d NOEC (Ceriodaphnia dubia, reproduction) = 0.204 mg/L (measured concentration, EPA-600/489/001)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.204 mg/L
Additional information
Since only the limited long-term information involving aquatic invertebrates is available for C16-18AS Na (CAS 68955-20-4), in accordance to Regulation (EC) 1907/2006 Annex XI, 1.5, a read-across to another structurally related category member was conducted. Read-across data from C16AS Na (CAS 1120-01-0) were used. The test results with the C18 homologue CAS 1120-04-3 were disregarded and are not presented. Since C18-AS Na is insoluble in calcium-containing water (i.e., Ceriodaphnia test waters), the effects (NOEC = 0.602 mg/L) are due to physical interactions, not the classic uptake into the organism and then elicit toxicity. For the PNEC derivation, the NOEC value determined for the C16 homologue is used as the worst case scenario of C16-18AS Na (CAS 68955-20-4).
The key, non-GLP, 7-day reproduction toxicity test with Ceriodaphnia dubia performed according to EPA-600/489/001 guideline is available for C16AS Na (CAS 1120-01-0, Lauth 1996). Daphnids were exposed under flow-through conditions to five test concentrations up to 1.29 mg/L (measured concentrations). Mortality and reproduction were evaluated daily. The NOEC value for reproduction determined after 7 days of exposure to test substance was 0.204 mg/L (measured concentration). This value is further used for derivation of PNEC freshwater value of C16-18AS Na (CAS 68955-20-4).
Moreover, a long-term test performed according to UBA procedure 16/85, No. 5 with C16-18AS Na (CAS 68955-20-4) is available (Steber 1988). Daphnia magna was exposed for 21 days under semi-static conditions to four test concentrations. The 21-day NOEC value based on reproduction was 16.5 mg/L (nominal concentration). No analytical monitoring of test concentrations is available.
An additional non-GLP long term test with C16-18AS Na (CAS 68955-20-4, Verge 2000) was performed according to OECD 202 guideline with Daphnia magna. Daphnids were exposed under semi-static conditions for 21 days to five concentrations of the test substance. No analytical monitoring is available. The 21-day EC50 value of 4.2 mg/L (nominal concentration) is provided.
For the PNEC calculation, the chronic NOEC value of 0.204 mg/L available for the pure homologue C16AS Na (CAS 1120-01-0) is used as the worst case scenario for C16-18AS Na (CAS 68955-20-4).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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