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EC number: 224-832-0 | CAS number: 4511-42-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- For QMRF and QPRF please see the attached documents below.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals, May 2008.
- Principles of method if other than guideline:
- (Q)SAR calculation
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): LL-lactide
- SMILES: CC1C(=O)OC(C(=O)O1)C (canonical); C[C@H]1C(=O)O[C@H](C(=O)O1)C (isomeric) - Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Value:
- 1.027
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Details on results:
- Biowin1 (Linear Biodeg Probability) 1.0273
Biowin2 (Non-Linear Biodeg Probability) 0.9999
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
Biowin3 (Survey Model - Ultimate Biodeg) 3.1611
Biowin4 (Survey Model - Primary Biodeg) 4.0977
Result Classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(Primary & Ultimate) 2.00 -> months 1.00 -> longer
Biowin5 (MITI Linear Biodeg Probability) 0.9965
Biowin6 (MITI Non-Linear Biodeg Probability) 0.9542
A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable
Biowin7 (Anaerobic Linear Biodeg Prob) 1.0995
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
The prediction is not dependent on stereochemistry. - Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- LL-lactide is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.10.
- Executive summary:
LL-lactide is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.10.
Reference
Description of key information
LL-lactide is considered to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
LL-lactide is predicted to be readily biodegradable by the validated QSAR model BIOWIN v4.10.
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