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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-09-04 to 2009-12-07
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
27 July 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
- Name of test material (as cited in study report): LL Lactide
- Batch no: 0902000694
- Appearance: white flakes, solid
- Purity: 100 %
- Expiration date of the lot/batch: 2010-02-10
- Stability under storage conditions: stable
- Storage: at room temperature in the dark
Key result
Water solubility:
16.7 g/L
Temp.:
20.1 °C
pH:
ca. 2
Details on results:
The results for the samples taken at 1, 2, 4, 6.5, 24 and 48 hours show, that concentration of the degradation product increased in time whereas concentration of LL Lactide remained stable over the first 24 hours. This indicates equilibrium between degradation and dissolving over this time period.
The significatly lower concentration at t= 48 hours was due to the fact that LL Lactide had dissolved somewhere between t=24 and t=48 hours and that most part had degraded.

Table 1: Main study- water solubility of the test substance
Stirring time Analysed [C] Mean [C] pH
[h] [g/L] [g/L] 1
1 17.2 16.7 2.2
2 17.8 2.1
4 16.1 2
6.5 16 1.8
24 16.5 1.5
48 1.3 1.3

1: mean of all concentrations over the first 24 hours

- time point 6 hours not determined due to a dilution error

Conclusions:
LL Lactide degrades rapidly in water. Water solubility of this test substance at 20.1 °C ± 0.6°C in the presence of excess undissolved LL-lactide, was determined to be 16.7 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.
Executive summary:

In this study the water solubility of LL-lactide (100 %) was determined in accordance to OECD TG 105. LL-lactide degrades rapidly in water. Water solubility of this test substance at 20.1 °C ± 0.6 °C in the presence of excess undissolved LL-lactide, was determined to be 16.7 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.

Description of key information

The water solubility of LL-lactide was determined to be 16.7 g/L.

Key value for chemical safety assessment

Water solubility:
16.7 g/L
at the temperature of:
20 °C

Additional information