Registration Dossier
Registration Dossier
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EC number: 212-757-6 | CAS number: 867-13-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- DermWin v 2.01
- Author:
- US Environmental Protection Agency
- Year:
- 2 011
- Bibliographic source:
- EPI Suite
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- QSAR model
Test material
- Reference substance name:
- Triethyl phosphonoacetate
- EC Number:
- 212-757-6
- EC Name:
- Triethyl phosphonoacetate
- Cas Number:
- 867-13-0
- Molecular formula:
- C8H17O5P
- IUPAC Name:
- ethyl 2-(diethoxyphosphoryl)acetate
Constituent 1
Results and discussion
- Absorption in different matrices:
- Skin penetration constant (Kp) (estimated): 0.000487 cm/hr
Any other information on results incl. tables
Results:
GENERAL Equation: log Kp = -2.80 + 0.66 log Kow - 0.0056 MW
Kp (predicted): 4.87e-004 cm/hr
Dermally Absorbed Dose per Event for Organic Compounds - Water Contact:
Water Conc (mg/cm3): 3.5 (estimated by program)
Fraction Absorbed : 1.0000
DA(event): 5.05e-003 mg/cm2-event (using eqn 3.2 & 3.3)
(tau = 1.93 hr, t* = 4.63 hr)
Dermally Absorbed Dose (70 kg Adult) - Water Contact:
DAD: 5.33e-001 mg/kg-day (using eqn 3.1)
Applicant's summary and conclusion
- Conclusions:
- The dermal permeability of Triethyl phosphonacetate is predicted to be relatively low.
- Executive summary:
The DERMWIN model, part of the US EPA EPIWIN Suite, estimated the skin penetration constant (Kp) to be 0.000487 cm/hr.
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