Registration Dossier

Administrative data

Endpoint:
dermal absorption, other
Remarks:
QSAR
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: QSAR model
Title:
DermWin v 2.01
Author:
US Environmental Protection Agency
Year:
2011
Bibliographic source:
EPI Suite

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR model

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Absorption in different matrices:
Skin penetration constant (Kp) (estimated): 0.000487 cm/hr

Any other information on results incl. tables

Results:

GENERAL Equation:  log Kp = -2.80 + 0.66 log Kow - 0.0056 MW

   Kp (predicted): 4.87e-004 cm/hr

 

Dermally Absorbed Dose per Event for Organic Compounds - Water Contact:

  Water Conc (mg/cm3): 3.5 (estimated by program)

  Fraction Absorbed : 1.0000

 

  DA(event): 5.05e-003 mg/cm2-event (using eqn 3.2 & 3.3)

                  (tau = 1.93 hr, t* = 4.63 hr)

 

Dermally Absorbed Dose (70 kg Adult) - Water Contact:

  DAD: 5.33e-001 mg/kg-day (using eqn 3.1)

Applicant's summary and conclusion

Conclusions:
The dermal permeability of Triethyl phosphonacetate is predicted to be relatively low.
Executive summary:

The DERMWIN model, part of the US EPA EPIWIN Suite, estimated the skin penetration constant (Kp) to be 0.000487 cm/hr.