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Physical & Chemical properties

Partition coefficient

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Description of key information

Experimental value Log Pow for the test item at 30°C: 1.13
Calculated value for Log Pow for the test item (QSAR): 1.23

Key value for chemical safety assessment

Log Kow (Log Pow):
1.13
at the temperature of:
30 °C

Additional information

The determination was carried out using an HPLC estimation method, according to Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 117 of the OECD Guidelines for testing of Chemicals, 13 April 2004 and GLP. No deviation from the Guidelines was observed.

In absence of any dissociating functional groups, no specific manipulation of the mobile phase pH was required. Therefore the determination was performed at an approximately neutral pH.

Regulatory guidance documents raise caution for the use of the HPLC estimation method for the determination of partition coefficient for surface active substances, as possible secondary interactions may occur between the test item and the HPLC column stationary phase. The absence of any such secondary interactions for this non-ionic surface active substance was strengthened in this case by the consistency between the computer estimated value of partition coefficient and that determined experimentally. Estimation of the partition coefficient from the saturation solubility of the test item in the individual solvents of n-octanol and water was not considered valid for this test item.  The miscibility of the test item in at least one of the solvents prevented obtaining any meaningful saturation concentrations, such that the estimation calculation process could not be completed.