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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

Additional information

Trifluoroacetic anhydride (TFAH, TFAA) is a dense and fluid liquid, considered as a Volatile Organic Compound.

It reacts, violently, with water, and also with air moisture to hydrolyse rapidly into the corresponding acid TFA, which is therefore is the actual and relevant species present in the environment.

TFA is fully miscible in water, where it will exist under its ionised form (acetate). The substance has low potential for bioaccumulation, and exhibits no surface-active properties.

Summary of relevant physico-chemical properties:




Colourless to pale yellow fuming liquid, with pungent odour.

Melting point

-64.2 °C

Boiling point

39.3 °C

Relative density

D204= 1.514

Vapour pressure

43.3 kPa at 20°C

Considered as a V.O.C.

Log Kow

0.79 (for hydrolysis product TFA)

Low bioaccumulation potential.

Water solubility

Fully miscible.

Surface tension

72,5 mN/m at 1 g/L and 20°C (for hydrolysis product TFA)

Not surface-active.


Explosive properties

Highly reactive. Self-classified with EUH014 (reacts violently with water).

If contact with metals, hydrogen release.

Oxidising properties

No oxidising properties (based on chemical structure).

 Dissociation constant

 pKa = 0.43 (for hydrolysis product TFA)

 Viscosity  1,8 mPa s at 20°C (for the analogue TFA)