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Description of key information

Short description of key information on absorption rate: 
Following very rapide hydrolysis of TFAH intoto TFA during skin contact at non irritant/corrosive concentrations, absorption of TFA may occur.

Key value for chemical safety assessment

Additional information

Trifluoroacetic anhydride (TFAH) is a dense and colourless fluid liquid, considered as a Volatile Organic Compound (VOC).

Considering the rapide hydrolysis of TFAH into TFA during its violent reaction with water and/or with air moisture (see §4), TFA is the relevant species for human exposed to TFAH by inhalation, by skin contact and by oral route. Hence, TFA has to be considered for human health hazard assessment.

TFA is fully miscible in water, where it will exist under its ionised form (acetate). The substance has low potential for bioaccumulation, and exhibits no surface-active properties (see §4).

TFA is rapidly absorbed by oral route. Absorption of TFA may occur after skin contact at non corrosive/irritant concentrations, considering both the moderate partition coefficient log Kow (0.79) and its high solubility in the water, together with its molecular mass (114 g/mol). Considered as a VOC, TFA vapor may be inhaled at room temperature and then absorbed considering the physico-chemical properties described above. After oral exposure, TFA is submitted to enteropatic circulation, then distributed in the body via the blood as ionised form considering its distribution coefficient log D (-0.58) and finally excreted mainly in the urine and in the bile (less extent) as parent compound.

Discussion on absorption rate:

Following very rapide hydrolysis of TFAH into TFA during skin contact at non irritant/corrosive concentrations, absorption of TFA may occur, considering both the moderate partition coefficient log Kow (0.79) and its high solubility in the water, together with its molecular mass (114 g/mol).

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