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Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

Trifluoroacetic anhydride (TFAH) is a dense and fluid liquid, considered as highly volatile. It reacts, violently, with water, and also with air moisture to hydrolyse rapidly into the corresponding acid TFA, which is therefore is the actual and relevant species present in the environment.


TFAH reacts with water and is rapidly degraded in TFA and therefore TFA is the compound of interest for the P-assessment. The results of standard respiration tests with activated sludge showed that TFA is not readily nor inherently biodegradable and non standard tests on several bacterial stains and different substrates showed that trifluoroacetic acid is not biodegradable under aerobic conditions. In conclusion, TFA was found to be highly resistant to abiotic and biotic degradation and therefore meets the P/vP criterion as stipulated in REACH Annex XIII.


The measured log Kow is 0.79 (for the hydrolysis product TFA), and hence the biocaccumulation potential is expected to be low. TFAH is therefore is not considered B or vB.


The measured acute effect concentrations of the hydrolysis product TFA are much higher than the screening criterion of 0.1 mg/l. It can therefore be expected that TFAH is not toxic towards aquatic organisms. The chronic effect concentrations for invertebrates are much higher than the definite criterion of 0.01 mg/l. TFAH is not classified as being a CMR and there is no evidence that it is chronically toxic towards mammals. Therefore the toxicity criteria stipulated in Annex XIII for toxicity are not met for TFAH.


The overall conclusions, of the PBT assessment are that the criteria for PBT / vPvB are not met, and that TFAH can be considered to be not PBT/vPvB.