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EC number: 211-479-2 | CAS number: 650-51-1
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August-October 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test method similar to OECD guideline 402, but no GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- TCA
- EC Number:
- 211-479-2
- EC Name:
- TCA
- Cas Number:
- 650-51-1
- Molecular formula:
- C2HCl3O2.Na
- IUPAC Name:
- trichloroacetic acid
- Details on test material:
- - Name of test material (as cited in study report): NaTA
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Auszuchtstamm the Tierzüchterei S. Ivanova, 7964 Kißlegg / Allgäu, PO Box 7
- Weight at study initiation: 100-105 g
- Housing: Animals were housed individually in Makrolon cages (type III).
- Diet (e.g. ad libitum): Altromin 1323 (From Altromin GmbH, Lage/Lippe). Ad libitum, except for the application day.
- Water (e.g. ad libitum): Ad libitum, except for the application day.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2 ºC
- Humidity (%): 60 ± 3 %
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
IN-LIFE DATES: August-October 1973
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: aqueous methyl-hydroxiethyl cellulose gel MH 300 P
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Intact dorsal skin.
- % coverage: 4.5 x 5 cm, 1/10 of body surface
- Type of wrap if used: 4-fold gauze, covered with aluminum foil and with an elastic plaster bandage (Elastoplast, 8 cm, BEIERSDORF AG, 2000 Hamburg 20) around the body.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): With warm water (30 ºC)
- Time after start of exposure: 24 hours
VEHICLE
- Amount(s) applied (volume or weight with unit): 5g/kg bw
- Concentration: 1% - Duration of exposure:
- 24 hours. During the exposure period, the animals were kept individually in glass tubes.
- Doses:
- 250, 500, 1000 and 2000 mg/kg
- No. of animals per sex per dose:
- 3 male and 3 female rats per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Skin reaction, general behavior and feed consumption were daily checked. Body weight were recorded at days 0, 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities were observed in any group of animals.
- Clinical signs:
- other: There were no changes in animal behavior.
- Gross pathology:
- No anatomicopathological alterations were found in any organ during the autopsies.
Any other information on results incl. tables
The LD 50 of sodium trichloroacetate was greater than 2000 mg/kg bw for rats.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC 50 of sodium trichloroacetate was greater than 2000 mg/kg bw for rats.
- Executive summary:
The study of Acute Dermal Toxicity of sodium trichloroacetate has been performed on male and female Sprague-Dawley rats. Four doses were tested (250, 500, 1000 and 2000 mg/kg bw) during 24 hours. For each dose level, a group of six rats (three males and three females), was exposed to this substance through dermal route. During a 14-day observation period, animals were daily controlled in what concerns cases of death, time of death, general behavior and food-consumption. Body weight was recorded at days 0, 7 and 14. At the end of the study all animals were sacrificed and macroscopically examined. According to the results obtained, the LD50 of sodium trichloroacetate was greater than 2000 mg/kg bw.
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