Registration Dossier
Registration Dossier
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EC number: 229-314-8 | CAS number: 6471-50-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 26 Sept 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Principles of method if other than guideline:
- Calculation of log Pow from solubility in octanol (see section 4.9) and water (see section 4.8).
- Type of method:
- other: Calculation
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 4-[(4-chloro-2-nitrophenyl)azo]-3-hydroxy-N-(2-methylphenyl)naphthalene-2-carboxamide
- EC Number:
- 229-314-8
- EC Name:
- 4-[(4-chloro-2-nitrophenyl)azo]-3-hydroxy-N-(2-methylphenyl)naphthalene-2-carboxamide
- Cas Number:
- 6471-50-7
- Molecular formula:
- C24H17ClN4O4
- IUPAC Name:
- 4-[(4-chloro-2-nitrophenyl)diazenyl]-3-hydroxy-N-(2-methylphenyl)-2-naphthamide
Constituent 1
Study design
- Analytical method:
- other: chromatography and UV-vis spectrometry
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 86.5
- Temp.:
- 22 °C
- pH:
- ca. 6.4
- Type:
- log Pow
- Partition coefficient:
- 1.94
- Temp.:
- 22 °C
- pH:
- ca. 6.4
- Details on results:
- The octanol and the water solubility were both determined at 22-23 °C.
It is not possible to enter a temperature range in the field above, therefore 22 °C was taken as the temperature value.
Any other information on results incl. tables
Calculation:
log Pow = log (c(n-octanol)/c(water))
(c: individual solubilities; see sections 4.8 and 4.9 and below).
Octanol solubility [µg/L] |
1090 |
Water solubility [µg/L] |
12.6 |
Applicant's summary and conclusion
- Conclusions:
- The calculated log Pow of the test substance is 1.94
- Executive summary:
The log Pow of the test substance was calculated from the solubility in octanol (see section 4.9) and the solubility in water (see section 4.8). The calculated log Pow of the test substance is 1.94 at 22 -23°C.
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