Registration Dossier
Registration Dossier
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EC number: 229-314-8 | CAS number: 6471-50-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publications which meet basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Photochemical cleavage of a tattoo pigment by UVB radiation or natural sunlight
- Author:
- Engel E, Spannberger A, Vasold R, König B, Landthaler M, Bäumler W
- Year:
- 2 007
- Bibliographic source:
- Journal der Deutschen Dermatologischen Gesellschaft 5: 583-589
- Reference Type:
- publication
- Title:
- Tattooing of skin results in transportation and light-induced decomposition of tattoo pigments - a first quantification in vivo using a mouse model
- Author:
- Engel E, Vasold R, Santarelli F, Maisch T, Gopee NV, Howard PC, Landthaler M, Bäumler W
- Year:
- 2 010
- Bibliographic source:
- Experimental Dermatology 19: 54-60
Materials and methods
- Type of study / information:
- Information on photochemical cleavage Pigment Red 22
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-hydroxy-4-[(2-methyl-5-nitrophenyl)azo]-N-phenylnaphthalene-2-carboxamide
- EC Number:
- 229-245-3
- EC Name:
- 3-hydroxy-4-[(2-methyl-5-nitrophenyl)azo]-N-phenylnaphthalene-2-carboxamide
- Cas Number:
- 6448-95-9
- IUPAC Name:
- 3-hydroxy-4-[(2-methyl-5-nitrophenyl)diazenyl]-N-phenyl-2-naphthamide
- Details on test material:
- - Name of test material (as cited in study report): Pigment Red 22 (PR 22)
- Analytical purity: > 98% (area % HPLC)
Constituent 1
Results and discussion
Any other information on results incl. tables
Experiment I:
After UVB-irradiation of PR 22 in solvents the decomposition products 2-methyl-5-nitroaniline (2,5 -MNA), 4 -nitrotoluene (4 -NT) were detectable. After sunlight exposure either 2,5 -MNA and 4 -NT or neither pigment nor decomposition products were detectable, depending on the solvent used. These data indicate that sunlight can cause complete mineralization.
Experiment II:
Pigment reduction during 42 days was about
- 32% in untreated skin;
- 60% in solar light treated skin;
- 51% in laser treated skin.
In laser treated skin 2-methyl-5-nitroaniline (2,5 -MNA), 4 -nitrotoluene (4 -NT) and naphtol AS (NAS) were detectable as decomposition products. The authors calculated that about 8% of decomposed PR 22 was directly detected as 2,5 -MNA and 4 -NT.
In solar light treated skin no 2,5 -MNA and 4 -NT products were detectable.
Applicant's summary and conclusion
- Conclusions:
- In vitro and in vivo investigations revealed that Pigment Red 22 can be decomposed by laser and sunlight.
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