4-[(4-chloro-2-nitrophenyl)azo]-3-hydroxy-N-(2-methylphenyl)naphthalene-2-carboxamide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Study period:

From 12 MAY 1981 to 26 MAY 1981

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Does not meet important criteria of today standard methods (diameter of particulates not determined, insufficient reporting of exposure concentration, no data on test item purity)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: company guideline similar to OECD guideline 403

Deviations:

no

GLP compliance:

no

Remarks:

GLP was not compulsory at the time the study was conducted

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-[[4-(aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide

EC Number:

220-509-3

EC Name:

4-[[4-(aminocarbonyl)phenyl]azo]-N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide

Cas Number:

2786-76-7

IUPAC Name:

4-[(4-carbamoylphenyl)diazenyl]-N-(2-ethoxyphenyl)-3-hydroxy-2-naphthamide

Test material form:

solid: particulate/powder

Remarks:

migrated information: particulates

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

nose only

Vehicle:

air

Analytical verification of test atmosphere concentrations:

yes

Remarks:

gravimetric

Duration of exposure:

4 h

Remarks on duration:

14 days observation period

Concentrations:

mean 1580 mg/cubic metre (787-2479)

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- test concentration was the highest technically feasible concentration

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 1 580 mg/m³ air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: no animal died during exposure or post observation period (highest technically feasible concentration)

Any other information on results incl. tables

- animals showed irregular breathing during exposure

- no animal died during exposure or post observation period

- normal body weight development during post observation period

- no macroscopic findings at necropsy

Applicant's summary and conclusion

Conclusions:

The test item was not toxic when administerd to rats via nose-only inhalation at the highest technically feasible concentration of 1580 mg per cubic metre.