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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, basic data given, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law
Author:
MITI
Year:
2002
Bibliographic source:
http://www.safe.nite.go.jp
Report date:
2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-isopropylaniline
EC Number:
202-797-2
EC Name:
4-isopropylaniline
Cas Number:
99-88-7
Molecular formula:
C9H13N
IUPAC Name:
4-(propan-2-yl)aniline

Test organisms

Test organisms (species):
Cyprinus carpio

Study design

Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
28 d

Results and discussion

Lipid contentopen allclose all
Lipid content:
3.46 %
Time point:
start of exposure
Lipid content:
3.33 %
Time point:
end of exposure
Bioaccumulation factoropen allclose all
Type:
BCF
Value:
6.4
Remarks on result:
other: Conc.in environment / dose:100 microg/L
Type:
BCF
Value:
8
Remarks on result:
other: Conc.in environment / dose:10 microg/L

Applicant's summary and conclusion

Executive summary:

The MITI study followed the OECD guidline 305 C. The experimental value of the BCF was 6.4 (Conc.in environment / dose:100 microg/L) and 8 (Conc.in environment / dose:10 microg/L)