Registration Dossier
Registration Dossier
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EC number: 202-797-2 | CAS number: 99-88-7
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary citation
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- IUCLID Dataset: 4-Isopropylanilin
- Author:
- ECB
- Year:
- 2 000
- Bibliographic source:
- European Chemical Bureau (ECB) European Commission 19.02.2000
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Guideline:
- other: Internal Guideline Hoechst AG
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-isopropylaniline
- EC Number:
- 202-797-2
- EC Name:
- 4-isopropylaniline
- Cas Number:
- 99-88-7
- Molecular formula:
- C9H13N
- IUPAC Name:
- 4-(propan-2-yl)aniline
- Test material form:
- other: liquid
- Details on test material:
- as prescribed in IUCLID Dataset
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- application of 1 ml once per day on 5 days
as undiluted testsubstance and
as 10 % solution (solvent not given) - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- once per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 ml undiluted testsubstance or 1 ml of a 10 % solution
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- application of 1 ml once per day on 5 days
as undiluted testsubstance and
as 10 % solution (solvent not given) - Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- details not reported
- Sacrifice and pathology:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Details on results:
- undiluted the tesubstance was strong irritating; as 10 % solution it is evaluated as irritating
Effect levels
- Dose descriptor:
- NOAEL
- Sex:
- not specified
- Basis for effect level:
- other: undiluted the tesubstance was strong irritating; as 10 % solution it is evaluated as irritating
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
Application of 1 ml once per day on 5 days as undiluted testsubstance or as 10 % solution (solvent not given).
Undiluted the tesubstance was strong irritating; as 10 % solution it is evaluated as irritating
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