Registration Dossier
Registration Dossier
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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 August and 28 September 1995.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Principles of method if other than guideline:
- Test substance (ca 1.0 g) was combined with distilled water (20 ml) in each of six 100 ml conical flasks. The flasks were firmly stoppered, covered in aluminium foil to exclude daylight and stirred at 30°C prior to equilibration at the test temperature of 20°C. The flask contents were stirred as indicated below:
Test Pre-equilibration Equilibration
(30°C) (20°C)
IA, 1B 3 Days 1 Day
2A, 2B 2 Days 1 Day
3A, 3B 1 Day 1 Day
Blanks were prepared and stirred as for the test solutions, omitting the test substance - GLP compliance:
- yes
- Type of method:
- flask method
- Remarks:
- flask-stirring method
Test material
- Test material form:
- other: White to off white crystalline solid
- Details on test material:
- Identity: UK-143,108
Chemical name: 2-Ethoxy-5-(4-methyl-1- piperazinesulphonyl)benzoic acid
Expiry: 19 November 1995
Purity: 99.6% (excluding organic solvents)
Appearance: White to off white crystalline solid
Storage conditions: Dark at room temperature
Date received: 19 May 1995
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 10.2 g/L
- Temp.:
- 20 °C
- pH:
- > 5.54 - < 5.8
- Remarks on result:
- other: +- 1C
- Details on results:
- recoveries of 100.0 and 99.8% (mean 99.9%).
No peaks were observed at the retention time of the test substance for either of the blanks showing that the analytical procedure was free from interferences
Any other information on results incl. tables
Testsample |
Integratedpeakarea |
Water solubility(g/l) |
Meanwatersolubilityforeach test (g/l) |
Overall meanwatersolubility(g/l) |
|
pH |
|||||
|
|||||
IA |
22125246 |
10.117 |
10.359 |
10.229 |
5.54 |
1B |
23193454 |
10.602 |
|
5.63 |
|
2A 2B |
22278564 22436666 |
10.186 10.258 |
10.222 |
5.71 5.80 |
|
3A |
21622814 |
9.8885 |
10.107 |
5.73 |
|
3B |
22583764 |
10.325 |
5.73 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of UK-143,108 has been determined as: 10.2 g/l at 20°C.
The pH at the saturation concentration ranged from 5.54 to 5.80
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