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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Version / remarks:
Comparable to international accepted guidelines.
Deviations:
not specified
GLP compliance:
no
Specific details on test material used for the study:
Name: FAT 40075/A
Purity: 74.5 %
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
14 °C
pH:
7.9-8.3
Nominal and measured concentrations:
100, 200 and 1000 mg/L
Duration:
48 h
Dose descriptor:
other: TL0
Effect conc.:
200 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL0
Effect conc.:
ca. 149 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL50
Effect conc.:
450 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL50
Effect conc.:
ca. 335 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL100
Effect conc.:
1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL100
Effect conc.:
ca. 745 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Details on results:
After 24 hrs: 8/8 fish survived at 100 and 200 mg/L. 2/8 fish survived at 1000 mg/L.
After 48 hrs: 8/8 fish survived at 100 and 200 mg/L. 0/8 fish survived at 1000 mg/L.
Sublethal observations / clinical signs:

Results:

Concentration
(mg/L)		 Surviving fish pH
24 h 48 h
 100 8 8 7.9
 200 8 8 8.0
 1000  2  0  8.3
Validity criteria fulfilled:
not specified
Conclusions:
The 48 h TL50 was found to be 450 mg/L (i.e. ca. 335 mg a.i./L).
Executive summary:

The acute fish toxicity test was performed using a method equivalent or similar to OECD Guideline 203. Fish were exposed to FAT 40075/A (purity: 74.5 %) for 48 hours at concentration of 100, 200 and 1000 mg/L. 8 fish per concentration were used for evaluation of toxicity. After 48 h, 8/8 fish survived at 100 and 200 mg/L. 0/8 fish survived at 1000 mg/L. Under the test conditions, the 48 h TL50 was found to be 450 mg/L (i.e. ca. 335 mg a.i./L).

Description of key information

Based on the data gathered from the study assessing the short term toxicity to fish, FAT 40075 was found to have 48h LC50 equal to 450 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
450 mg/L

Additional information

The acute fish toxicity test was performed using a methodology equivalent or similar to OECD Guideline 203. Fish were exposed to FAT 40075/A (purity: 74.5 %) for 48 hours at concentration of 100, 200 and 1000 mg/L. 8 fish per concentration were used for evaluation of toxicity. After 48 h, 8/8 fish survived at 100 and 200 mg/L. 0/8 fish survived at 1000 mg/L. Under the test conditions, the 48 h TL50 was found to be 450 mg/L (i.e. ca. 335 mg a.i./L).