Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Test Item: FAT 40075/D
Lot: BOP 01-12
Water solubility:
334 g/L
Temp.:
20 °C
Remarks on result:
other: pH is not known

Preliminary Visual Estimation of the Water Solubility

 

Appearance of the test mixtures in the preliminary test

Amount of the test item in mg

 

Total volume in ml

 

Appearance of mixture

 

100

 

0.1

Undissolved

0.5

Dissolved

 

The preliminary visual experiments showed that the water solubility of the test item is >200 g/l and <1000 g/l . Therefore the water solubility had to bo determined by the “flask method”.

Due to the high water solubility it was tested which amount of the test substance could be stirred in a defined volume of water.

Appearance of the test mixtures in the stirring test

volume of waterin ml

mass of the added test item

in g

total mass of the test item

in g

Appearance of mixture

 

2

1.0

1.0

solution is stirrable

2

+0.5

1.5

solution is stirrable

2

+0.5

2.0

could not be stirred

2.5

---

2.0

solution is stirrable

 

Due to this stirring experiment the main test could be performed with 2.0 g in 5 ml water (400 g/l) This solution was stirred at 20 °C for 22 hours. After this time a dark coloured pasty solution was observed. No precipitate was observed. The stirring test showed that 400 g/l test item can be used for flask method.

 

Flask-Method

Water solubility of the test item – experiments A to D

Experiment

 

A

 

B

 

C

 

D (blank)

 

Amount of test item(g)

2.0

2.0

2.0

---

Stirring time at 30°C (h)

24

48

72

72

Aliquot of the flasks μl/10/0.40/10

10.0

10.0

10.0

10.0

Measured concentration (μg/ml)

13.2

13.6

13.3

---

Water solubility (g/l)

328

341

332

---

 

Average experiments A to C: 334 g/l

Standard deviation: 10.2 g/l

Relative standard deviation: 3.1 %

Conclusions:
The water solubility of the test item at a temperature of 20 °C was determined to be 334 g/l.
Executive summary:

The water solubility of FAT 40075/D was evaluated in a study conducted according to OECD Guideline 105. Flask method was used for this purpose. based on the findings of the study, the water solubility of the test item at a temperature of 20 °C was determined to be 334 g/l.

Description of key information

The water solubility of FAT 40075/D was evaluated in a study conducted according to OECD Guideline 105. Flask method was used for this purpose. Based on the findings of the study, the water solubility of the test item at a temperature of 20 °C was determined to be 334 g/l.

Key value for chemical safety assessment

Water solubility:
334 g/L
at the temperature of:
20 °C

Additional information