Registration Dossier
Registration Dossier
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EC number: 231-561-1 | CAS number: 7632-51-1
Endpoint summary
Administrative data
Description of key information
VCl4 is the least stable vanadium chloride. Its decomposition is driven by heat, dissolved Cl2 concentration, humidity or light, following the equation:
VCl4 + H2O => VOCl2 + 4 HCL
The dissolution reaction in water (body humidity....) is exothermic, instantaneous (half-life of VCl4 < 1 hour – VCl4 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.
Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive and test for a sensitisation are not performed for animal welfare considerations.
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Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the available information indicates that the substance should be classified for respiratory sensitisation or corrosivity
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the available information indicates that the substance should be classified for respiratory sensitisation or corrosivity
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
With the physico-chemical property (HCl generation) and the weight of evidence (industrial practise), VCl4 is considered as corrosive.
Justification for classification or non-classification
With the physico-chemical property (HCl generation) and the weight of evidence (industrial practise), VCl4 is considered as corrosive and tests for sensitization are not necessary. No classification for sensitization could therefore be set.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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