Registration Dossier

Administrative data

Description of key information

VCl4 is not a stable vanadium chloride. Its decomposition is driven by heat, dissolved Cl2 concentration, humidity or light, following the first equation:

VCl4 + H2O => VOCl2 + 4 HCL

The dissolution reaction in water (body humidity...) is exothermic, instantaneous (half-life of VCl4 < 1 hour – VCl4 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.

Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive and test for acute toxicity are not performed for animal welfare considerations.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

With the physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive and test for acute toxicity are not performed for animal welfare

considerations. For this reason, no classification for acute toxicity could be set.

Some oral LD50 are collected but due the date of data (1969) and the absence of details, this LD50 is not selected for classification. And, it is possible the cause of death is the effect of the corrosive property on the digestive tracts.