Registration Dossier

Administrative data

Description of key information

VCl4 is the least stable vanadium chloride. Its decomposition is driven by heat, dissolved Cl2 concentration, humidity or light, following the equation:

VCl4 + H2O => VOCl2 + 4 HCL

The dissolution reaction in water (body humidity....) is exothermic, instantaneous (half-life of VCl4 < 1 hour – VCl4 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.

Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive and test for a sensitisation are not performed for animal welfare considerations.

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Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Referenceopen allclose all

Endpoint:
skin sensitisation: in vitro
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the available information indicates that the substance should be classified for respiratory sensitisation or corrosivity
Endpoint:
skin sensitisation: in vivo (LLNA)
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the available information indicates that the substance should be classified for respiratory sensitisation or corrosivity
Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

With the physico-chemical property (HCl generation) and the weight of evidence (industrial practise), VCl4 is considered as corrosive.

Justification for classification or non-classification

With the physico-chemical property (HCl generation) and the weight of evidence (industrial practise), VCl4 is considered as corrosive and tests for sensitization are not necessary. No classification for sensitization could therefore be set.