Registration Dossier

Administrative data

Description of key information

VCl4 is not a stable vanadium chloride. Its decomposition is driven by heat, dissolved Cl2 concentration, humidity or light, following the equation:

VCl4 + H2O => VOCl2 + 4 HCl

The dissolution reaction in water (body humidity...) is exothermic, instantaneous (half-life of VCl4 < 1 hour – VCl4 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.

Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin corrosion: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Justification for classification or non-classification

With the physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl4 is considered as corrosive on the criteria basis of the CLP regulation.

It is not possible to assign a sub-category on basis on physico-chemical effects, and it makes no differences in classification or any other aspect in supply systems based on GHS whether a corrosive substance is category 1A, 1B or 1C as the symbol, the signal word and hazard assessment are all the same.

But these corrosive sub-categories apply to some authorities and in transport, assigning or changing the packing group is particularly significant as it determines the requirements for the containment system and downstream consequences relating to the transport operation. The relationship between ADR (Agreement on Dangerous goods by Road) classification and GHS corrosive classification has been evaluated by the Committee of Experts on the Transport of Dangerous Goods and on the Globally Harmonized System of classification and Labelling of Chemicals, on 2012 and 2013 (ref. UN/SCETDG/41/ INF.53, UN/SCEGHS/23/INF.18, ST/SG/AC.10/C.3/2013/68 and ST/SG/AC.10/ C.4/2013/8)

The committee concluded on the alignment for packing group I (and hazard class 8, the ADR classification for VCl4) with Skin corrosion Cat 1A.