Registration Dossier
Registration Dossier
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EC number: 690-526-2 | CAS number: 38632-47-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
A valid Ames test, an in-vitro Chromosome Aberration test and a HPRT test, in chinese hamster V79 cells with 1,1 '-(1 ,6-Hexanediyldiimino)- bis[1 -oxo-methanesulfonic acid], sodium salt (1 :2), was negative.
A micronucleus assay in bone marrow cells of the mouse with 1,1’-(1,6-Hexanediyldiimino)bis[1-oxomethanesulfonic acid], sodium salt (1:2) according to OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test) was also negative
Justification for selection of genetic toxicity endpoint
In vivo MNT test has been conducted in addition to Ames test, in-vitro chromosome abberation test and HPRT test, since it's required for the registration in China.
Short description of key information:
in vitro:
Ames test: negative
Cytogenetic assay: negative
mammalian cell gene mutation test: negative
in vivo:
MNT: negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
All available genetic toxicity assays showed a negative result. Therefore a classification is not justified.
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