Methanesulfonic acid, 1,1'-(1,6-hexanediyldiimino)bis[1-oxo-, sodium salt (1:2)

Endpoint summary

Description of key information

An acute oral toxicity study according OECD TG 423 was conducted. Two x three female rats received a single dose of X-TAN (preparation of hexamethylen diisocyanatebisulfite-adducte in water). Up to 2000 mg/kg of a  31% X-Tan solution was tested. No mortalities or clinical signs were observed.
An acute inhalation toxicity test acording OECD 403 was conducted with rats to determine the potential for the aerosolized dust of 1,1' -(1 ,6-Hexanediyldiimino)bis[l-oxo-methanesulfonic acid], sodium salt (1 :2) to produce toxicity via the inhalation (nose-only exposure) route.
In an acute dermal toxicity study according OECD 402 five male and five female RccHan:WIST (SPF) rats were treated with 1,1’-(1,6- Hexanediyldiimono)bis[1-oxo-methanesulfonic acid], sodium salt (1:2) at the limit dose of 2000 mg/kg by dermal application. 

Additional information

In the acute oral toxicity study a dose of 2000 mg/kg body weight of a 31% aquous solution of X-Tan (content of active substance was not used for calculation

was tolerated by female rats without mortalities, clinical signs, toxicological effects on weight gain and gross pathological findings.

The single exposure acute inhalation LC50 of the test substance is greater than 5.57 mg/L in male and fe male rats. All animals survived exposure to the test atmosphere. No gross abnormalities were noted of the animals when necropsied at the end of the 14-day observation period.

In acute dermal toxicity study no intercurrent deaths occurred during the course of the study. No clinical signs were recorded throughout the entire observation period and no macroscopic findings were found at necropsy.

Justification for classification or non-classification

Due to the results of the acute oral, acute inhalation and acute dermal toxicity study a classification for the test item is not justified.