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EC number: 248-256-4
CAS number: 27138-01-8
All animals appeared active and healthy. There were no signs of
gross toxicity, adverse pharmacology effects or abnormal behavior. No
gross pathological changes were observed at necropsy.
contact hypersensivity of the meta-diols was evaluated in Guinea pigs
according to OECD N°406 guideline (Buehler test).
On day 0, 7 and 14, the test and positive control group animals
were given induction exposure; the negative control animals were not
treated. On day 28, all the three groups were given challenge exposure
on the opposite intact skin. Skin reactions
were scored at 24 and 48 hours after completion of the challenge
Positive reactions were not observed in the test group animals at
the 24-hour and 48-hour examination; the sensitization rate was
0%. Erythema occurred in 10 animals in the positive control group; the
sensitization rate was 66.7%. There were no positive skin responses in
the negative control group; the sensitization rate was 0%. There was no
mortality, and there were no remarkable clinical observations in any
conclusion, under these experimental conditions, meta-diols was
considered as non-sensitizing in the Buehler test.
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