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EC number: 248-256-4
CAS number: 27138-01-8
The potential of
a,a,a',a'-tetramethyl-m-xylene-a,a'-diol to induce ocular irritation was
evaluated in rabbits according to OECD guideline.
Four healthy Japanese white rabbits were
taken for the test. 0.1 g of the test substance was put into the left
eye of four healthy rabbits. The right eye was treated with 0.1 ml
normal saline and served as control. The
right/left eye was not treated and served as control. The eyes were not
rinsed after administration of the test item. Ocular
reactions were observed approximately 1 hour, 24, 48 and 72 hours after
No eye reactions occurred after exposure
until the 72 h. Therefore the rabbits were not observed anymore.
In conclusion, under
these experimental conditions, the test item is not irritant when
administered by ocular route to rabbits.
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