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Short-term toxicity to aquatic invertebrates

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Description of key information

48h EC50 for m/p DIOL to D. magna is > 100 mg/L, based on nominal concentrations of m/p DIOL. The 48h no observed effect concentration (NOEC) is concluded to be 100 mg/L.

Key value for chemical safety assessment

Additional information

The acute toxicity to Daphnia magna was evaluated for the meta-isomer as well as for the mixture of both isomers according to OECD Guideline 202.

 

One study was designed to estimate the median effect concentration (EC50) for immobilisation of Daphnia magna exposed to the reaction mass of a,a,a’,a’-tetramethyl-m-xylene-a,a’-diol and a,a,a’,a’-tetramethyl-p-xylene-a,a’-diol (m/p DIOL). This study was conducted of a 48h period, under semi-static conditions. Four replicate vessels were prepared for each treatment group, each containing five D. magna neonates. No immobile D. magna were recorded in the control or 100 mg/L nominal concentration throughout the test period. It is concluded that the 48h- EC50 for m/p DIOL to D. magna is > 100 mg/L, based on nominal concentrations of m/p DIOL. The 48h no observed effect concentration (NOEC) is concluded to be 100 mg/L.

 

A test performed according to “The guidelines for the testing of chemicals” (HJ/T 153 -2004) and with reference to Procedure 202 of the “Guidelines for Testing of Chemicals” of the OECD: “Daphnia sp., Acute Immobilisation Test” (2004) etc. was designed to determine the acute toxicity of meta-Diisopropanolbenzene.The study comprised at least one range-finding test followed by a limit test to determine the 48-hour median effective concentration (EC50) of the test substance. In addition, the NOEC (no observed effect concentration) was also determined.

Under valid test conditions the 48h EC50 is greater than 150 mg/L (nominal concentration). And 48h NOEC value (no observed effect concentration) is greater than 150 mg/L (nominal concentration).

 

To conclude, no immobilization was observed throughout both tests at their highest tested concentration. As a consequence, 48h-EC50 is considered to be > 100 mg/L