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EC number: 248-256-4
CAS number: 27138-01-8
48h EC50 for m/p DIOL to D. magna is > 100 mg/L, based on nominal concentrations of m/p DIOL. The 48h no observed effect concentration (NOEC) is concluded to be 100 mg/L.
The acute toxicity to Daphnia
magna was evaluated for the meta-isomer as well as for the mixture
of both isomers according to OECD Guideline 202.
One study was designed
to estimate the median effect concentration (EC50) for immobilisation of Daphnia
magna exposed to the reaction mass of
a,a,a’,a’-tetramethyl-p-xylene-a,a’-diol (m/p DIOL). This study was
conducted of a 48h period, under semi-static conditions. Four replicate
vessels were prepared for each treatment group, each containing five D.
magna neonates. No immobile D. magna were recorded in the
control or 100 mg/L nominal concentration throughout the test period. It
is concluded that the 48h- EC50 for m/p DIOL to D. magna is > 100
mg/L, based on nominal concentrations of m/p DIOL. The 48h no observed
effect concentration (NOEC) is concluded to be 100 mg/L.
A test performed
according to “The guidelines for the testing of chemicals” (HJ/T 153
-2004) and with reference to Procedure 202 of the “Guidelines for
Testing of Chemicals” of the OECD: “Daphnia sp.,
Acute Immobilisation Test” (2004) etc. was designed to determine the
acute toxicity of meta-Diisopropanolbenzene.The
study comprised at least one range-finding test followed by a limit test
to determine the 48-hour median effective concentration (EC50) of the
test substance. In addition, the NOEC (no observed effect concentration)
was also determined.
Under valid test
conditions the 48h EC50 is greater than 150 mg/L (nominal
concentration). And 48h NOEC value (no observed effect concentration) is
greater than 150 mg/L (nominal concentration).
To conclude, no
immobilization was observed throughout both tests at their highest
tested concentration. As a consequence, 48h-EC50 is considered to be >
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