Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-256-4 | CAS number: 27138-01-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48h EC50 for m/p DIOL to D. magna is > 100 mg/L, based on nominal concentrations of m/p DIOL. The 48h no observed effect concentration (NOEC) is concluded to be 100 mg/L.
Key value for chemical safety assessment
Additional information
The acute toxicity to Daphnia magna was evaluated for the meta-isomer as well as for the mixture of both isomers according to OECD Guideline 202.
One study was designed to estimate the median effect concentration (EC50) for immobilisation of Daphnia magna exposed to the reaction mass of a,a,a’,a’-tetramethyl-m-xylene-a,a’-diol and a,a,a’,a’-tetramethyl-p-xylene-a,a’-diol (m/p DIOL). This study was conducted of a 48h period, under semi-static conditions. Four replicate vessels were prepared for each treatment group, each containing five D. magna neonates. No immobile D. magna were recorded in the control or 100 mg/L nominal concentration throughout the test period. It is concluded that the 48h- EC50 for m/p DIOL to D. magna is > 100 mg/L, based on nominal concentrations of m/p DIOL. The 48h no observed effect concentration (NOEC) is concluded to be 100 mg/L.
A test performed according to “The guidelines for the testing of chemicals” (HJ/T 153 -2004) and with reference to Procedure 202 of the “Guidelines for Testing of Chemicals” of the OECD: “Daphnia sp., Acute Immobilisation Test” (2004) etc. was designed to determine the acute toxicity of meta-Diisopropanolbenzene.The study comprised at least one range-finding test followed by a limit test to determine the 48-hour median effective concentration (EC50) of the test substance. In addition, the NOEC (no observed effect concentration) was also determined.
Under valid test conditions the 48h EC50 is greater than 150 mg/L (nominal concentration). And 48h NOEC value (no observed effect concentration) is greater than 150 mg/L (nominal concentration).
To conclude, no immobilization was observed throughout both tests at their highest tested concentration. As a consequence, 48h-EC50 is considered to be > 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
