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EC number: 248-256-4
CAS number: 27138-01-8
dermal irritation of the meta-diols isomer was evaluated in rabbits
according to OECD 404 guideline.
Four healthy Japanese white rabbits were
taken for the test. 0.5g test substance was applied to an area of shaved
skin on left of back of four healthy rabbits and the application site
was covered with a semi-occlusive dressing for four hours. Following
exposure, dermal irritation was evaluated by at 24, 48 and 72h after
removal of the dressing. No erythema was observed on the treated skin
area of any rabbit. There was no erythema on the control area of the
rabbits. The average score of skin responses was 0. In conclusion, under
the experimental conditions of the test,
a,a,a',a'-tetramethyl-m-xylene-a,a'-diol is considered as non-irritant
when applied topically to rabbit skin.
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