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EC number: 225-590-9
CAS number: 4948-15-6
To test the skin and mucous membrane tolerability the test substance was digested in 0.9% NaCl solution for 1 hour at 40°C in a heating cabinet, the amount being 2.5 g in 25 ml NaCl solution. The solution was then filtered off and the aqueous filtrate obtained. Three rabbits of the yellow-silver breed were used as the experimental animals in each test. The test for skin tolerability was carried out using the Barail test by intracutaneous injection of in each case 0.02 ml of the undiluted filtrate or the filtrate diluted 1:10, 1:100 or 1:1000 into the depilated flank skin. 0.02 ml of 0.9% NaCl solution was injected for control purposes. All the injections were well tolerated without reaction. In a further test the undiluted aqueous filtrate was applied 5 times in 5 days in a quantity of 0.5 ml each time to the depilated and intact flank skin of rabbits. No signs of irritation were observed. Based on these results, the substance was considered to be not irritating.
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