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EC number: 225-590-9
CAS number: 4948-15-6
Table 1: Results with detection by UV-Vis
Static dissolution, PSF shaker, dissolved fraction
Dynamic dissolution, Max observed concentration
Dynamic PSF dissolution rate k
< 0.001 ng/cm²/h
< 0.1 mg/L
The static solubility was examined by suspending the test item in phagolysosomal simulant fluid at pH 4.5 for 24h. Thereafter the dissolved fractions were detected by UV-Vis. The test item was insoluble with less than 0.05% dissolved fraction.
The dynamic dissolution assay is an abiotic flow-through method to determine the biodissolution of materials in relevant lung fluids. The flow cell mimics the non-equilibrium physiological conditions, where ions can be transported away from the lungs. A phagolysosomal simulant media with a low pH value (4.5) was used because alveolar macrophages collect and engulf the vast majority of inhaled pulverulent particles from the alveolar surface, and rapidly transfer them into acidic phagolysosomes. The test was performed over seven days, at 37°C. The test item was insoluble with dissolution rates below 0.001 ng/cm²/h.
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