Registration Dossier
Registration Dossier
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EC number: 225-590-9 | CAS number: 4948-15-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: ETAD method
- Principles of method if other than guideline:
- Estimation based on individual solubilities.
The analytical method for the determination is in agreement with the method that was agreed upon at the "Analytical Experts Meeting" ofETAD (Basel) on January 12, 2005. - GLP compliance:
- no
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- voltammetric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.13
- Temp.:
- 23 °C
- Remarks on result:
- other: pH value not available
- Details on results:
- The solubility of the sampie "Pigment Red 149" in water at ambient temperature, determined under the conditions as mentioned below, is 1.4 ~g per liter (0' = 0.6).
The solubility of the sampie "Pigment Red 149" in octanol at ambient temperature, determined under the conditions as mentioned below, is 1.9 ~g per liter (0' = 0.3). - Conclusions:
- The partition coefficient of test substance was estimated to be log Pow= 0.13 at 23°C.
Reference
Estimation of log Pow:
Pow= C(n-octanol) / C(water)= 1.9 µg/L / 1.4 µg/L = 1.35714
log Pow= 0.13
Description of key information
Estimated based on solubility ratio:
log Pow= 0.13 at 23°C
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.13
- at the temperature of:
- 23 °C
Additional information
The partition coefficient was estimated based on the individual solubilities.
The determination of solubilities in water and in n-octanol was carried out by flask method according to OECD Guideline 105 and also by the ETAD method. This standard method was developed by intensive cooperation with the ETAD (Ecological and Toxicological Association of Dyesand Organic Pigments Manufacturers) and is regarded as acceptable for pigments.
The study based on ETAD method had been chosen as key study since the test substance was purified.
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