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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and sufficient documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
500 mg of the test substance were semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4.3 kg) for an exposure period of 4 hours. Evaluation of skin irritation was made until day 7 according to Draize
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Bayplast Gelb 5G
IUPAC Name:
Bayplast Gelb 5G
Details on test material:
Bayplast Gelb 5G

Test animals

Species:
rabbit
Strain:
other: HC:NZW

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: shorn
Vehicle:
water
Controls:
not required
Duration of treatment / exposure:
4 hours
Observation period:
7 days
Number of animals:
3 animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48, and 72 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48, and 72 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point

Any other information on results incl. tables

no erythema and no edema was evident (score = 0 at any time point)

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

500 mg of the test substance were semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4.3 kg) for an exposure period of 4 hours. Evaluation of skin irritation was made until day 7 according to Draize. No erythema and no edema was evident (score = 0 at any time point).

Bayplast Gelb 5G = Nickel, 5,5'-azobis-2,4,6(1H,3H,5H)-pyrimidinetrione complexe was 'not irritating to the skin' (exposure period: 4 hrs).