Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-379-0
CAS number: -
Two studies for skin irritation according OECD 404 with Bayplast Gelb 5G and Bayplast Gelb 5 GN 01 are available.An eye irritation study according OECD 405 (LPT 2013) and an in-vitro study on a 3D-cornea model with Bayplast E4GN are available. Additional 2 studies with Bayplast Gelb 5G and Bayplast Gelb 5 GN 01 were conducted.
In the key study for skin irritation/corrosion the test substance was not irritating (erythema and edema score: 0 of max. 4; 24, 48, and 72 h).
In the key study for eye irritation the exposure of the test substance to the eye caused conjunctival redness (grade 1) in all animals 60 minutes and 24 hours after administration, in animal nos. 1 and 3 until 48 hours after administration. The corneae and irises were not affected by administration of the test item. This finding is supported by an in vitro study for assessing ocular irritation of compounds using a human epithelial corneal cell model, in which Gelbpigment E4GN is predicted as non-irritant to eyes.
Eye irritation studies with Bayplast Gelb 5G and Bayplast Gelb 5 GN 01 showed some irritation whereas studies with Gelbpigment E4GN showed no eye irritation potential. Since Gelbpigment E4GN is well characterized and a representative and recent compound preparation the data on Gelbpigment E4GN are considered to be more relevant than the data on the earlier compound preparations Bayplast Gelb 5G and Bayplast Gelb 5 GN 01, which might contain additives and/or additional impurities responsible for the observed effects. Since no relevant skin irritation and no acute oral toxicity were observed with Bayplast Gelb 5G and/or Bayplast Gelb 5 GN 01 no additional testing was conducted for these endpoints.
Due to results of the key study for skin irritation (erythema and edema score 0 of 4) and the key study for eye irritation (conjuctivae score 0.55 of 3) a classification for skin irritation and eye irritation is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again