Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

There are no toxicokinetic studies available.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Nickel, 5,5'-azobis-2,4,6(1H,3H,5H)-pyrimidinetrione complexes (Gelbpigment E4GN) is insoluble in water (the water solubility of the test item in demineralized water was 0.08 mg/L at 20 °C and pH 6.2.) and has a log Pow of -2.63 (estimated value with EPIWIN using the formula of the nickel free substance. The model KOWWIN included in the Estimation Program Interface (EPI) Suite v4.11 revealed a value of - 2.63 of the substance).

Gelbpigment E4GN has a low acute toxicity (LD50 oral >5000 mg/kg bw ; LC50 inhalation > 5222 mg/m³). The substance is not irritating to the skin and eyes and has no sensitising potential. Gelbpigment E4GN was negative in all in-vitro gene mutation assays with and without metabolic activation. No toxification via metabolic activation of parent compounds are therefore expected. The NOAEL in a repeated dose study was 1000 mg/kg bw.