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EC number: 284-895-5
CAS number: 84989-06-0
The fraction of tar acids, rich in 2,4- and 2,5-dimethylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
survived the treatment. In males, urine stained fur and excessive
salivation was observed at all dose levels. Body weight gain and food
consumption were unaffected by treatment. Neurotoxicity was not observed
during the study and there were no treatment related effects observed at
gross necropsy or histopathologically. Urine staining of the fur was
observed in females at the 245 mg/kg bw/day level. F1 animals showed no
treatment related clinical or necropsy signs. Relative weights of the
kidney, liver and ovaries were observed to be increased in the 245 mg/kg
bw/day treatment group.
effects are discussed under section 7.8.1.
All rats survived the treatment. In males,
urine stained fur was observed at the 245 mg/kg bw/day level. Body
weight gain and food consumption were unaffected by treatment. Mating
frequency was reduced at the 245 mg/kg bw/day level. Neurotoxicity was
not observed during the study and there were no treatment related
effects observed at gross necropsy or histopathologically. Urine
staining of the fur was observed in females at the 245 mg/kg bw/day
level. F1 animals showed no treatment related clinical or necropsy
signs. Haematology and clinical pathology parameters were unaffected.
Reproductive indices are discussed under
no deaths, body weight gain comparable to control group, no untoward behavioral reactions, at autopsy, relative organ weights (liver, kidneys, adremals and testes) of treated males did not differ from relative organ weights of the control animals; no significant gross lesions were noted among experimental animals when compared to control animals.
In the result table above the most critical value of the weight of
evidence approach is given. In the following, the results are shown for
the other source substances of this weight of evidence approach:
Source CAS 108 -39 -4: m-cresol: NOAEL (male, rat) = 300 mg/kg bw/day,
based on histopathological changes in the liver; MHLW, 2001
Source CAS 108 -39 -4: m-cresol: NOAEL (female, rat) = 100 mg/kg bw/day,
based on increased relative liver weight; MHLW, 2001
Source CAS mixed ethylphenols: NOAEL (male/feamle, rat) = 100 mg/kg
bw/day, based on clinical observations (urine-stained fur, increased
kidney, liver and ovarian relative weight); Merisol, 2005
There is an additional study with p-cresol. Male rats were fed with 0,
10, 150, 500 ppm (0, 1.90, 14.2, 45.2 mg/kg bw/d) p-cresol (CAS
106-44-5) for 28 days. No treatment related effects were reported. Thus,
the NOAEL is 500 ppm (45.2 mg/kg bw/d) under the conditions of this
test. However, the study was assessed as not reliable as it was
conducted at IBT laboratories in 1969. During the 1960s until 1978
significant discrepancies and deficiencies were noted at least in
long-term studies of IBT laboratories. Therefore, this study was
disregared and assessed as not reliable for hazard assessment of the
The sub-acute repeated dose oral toxicity studies conducted on mixed
ethyl phenols and mixed xylenols confirm a NOAEL at 100 mg/kg bw/day for
both test materials. The study on m-cresol shows that the NOAEL is quite
similar to that obtained for mixed xylenols and mixed ethylphenols
(NOAEL(males) = 300 and NOAEL(females) = 100 mg/kg bw/day, which
strengthens the argument that the structural similarities of these
compounds provides reliable read-across approach to the target
Increases in liver and/or kidney weights were reported. No
histopathological changes accompanied these increases in organ weights
(with the exclusion of 1000 mg/kg bw/day of m-cresol which reported
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