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EC number: 284-895-5
CAS number: 84989-06-0
The fraction of tar acids, rich in 2,4- and 2,5-dimethylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
p-Cresol was applied to the skin of 30 males. Hair colour
was observed weekly for the subsequent 6 months. Microscopic examinations of post-treatment hairs and skin
biopsies of areas of non-pigmented and normally pigmented
hair were made. Control groups of animals received acetone.
Topical application caused depigmentation of the hair and
pigmented epidermis, especially of the tail. Large amounts
of p-cresol were lethal and had a local caustic erosive effect.
The available data is not reliable for hazard assessment of Tar acids,
Xylenol fraction (CAS 84989-06-0). Further testing is, however, not
required, as there are reliable oral repeated dose toxicity data
available for the hazard assessment of Tar acids, Xylenol fraction (CAS
84989-06-0) and therefore, the requirements defined in Regulation (EC)
No 1907/2006, Annex IX, 8.6 are fulfilled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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