Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 209-090-8 | CAS number: 555-31-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis. Grade 1 indicates a very small area of necrosis resulting from 0.5 mL of undiluted chemical in the eye.
- GLP compliance:
- no
- Remarks:
- the study was conducted prior adoption of GLP
Test material
- Reference substance name:
- Tripropylamine
- EC Number:
- 203-047-7
- EC Name:
- Tripropylamine
- Cas Number:
- 102-69-2
- Molecular formula:
- C9H21N
- IUPAC Name:
- N,N-dipropylpropan-1-amine
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): tripropylamine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0-3.5 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- single exposure
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corneal injury in rabbits
- Basis:
- mean
- Time point:
- other: not reported
- Score:
- 1
- Max. score:
- 10
- Reversibility:
- other: very small area of necrosis
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- According to the study results, tripropylamine produces "very small area of necrosis" after instillation of 0.5 mL of test material in eyes of rabbits. Tripropylamine is considered to be corrosive to eyes
- Executive summary:
Tripropylamine was tested in a range-finding toxicity study in albino New Zealand rabbits (Smyth et al., 1969). Eye injury in rabbits was recorded in a 10-grade ordinal series and was based upon the degree of corneal necrosis that resulted from instillation of 0.5 mL of undiluted test material in the eyes of animals. Grade 1 established for tripropylamine indicates a very small area of necrosis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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