Registration Dossier
Registration Dossier
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EC number: 211-541-9 | CAS number: 660-68-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1950
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from peer-reviewed handbook
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 950
- Report date:
- 1950
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- Smyth, H.F. et al.
- Year:
- 1 951
- Bibliographic source:
- Arch. Ind. hyg. occup. med. 4: 119-122
- Reference Type:
- secondary source
- Title:
- Industrial Hygiene and Toxicology
- Author:
- Sutton W.L.
- Year:
- 1 962
- Bibliographic source:
- cited in: Patty's Ind.Hyg. and Toxicol. 2, 2044
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- before 1981
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- diethylamine (CAS: 109-89-7)
- IUPAC Name:
- diethylamine (CAS: 109-89-7)
- Test material form:
- other: clear liquid
- Details on test material:
- - Name of test material (as cited in study report): Diethylamine
- Physical state: clear liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 90-120 g
- Diet: Rockland rat diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 % - Doses:
- 252, 500, 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 (m)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: day 0, 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 540 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 350 - 830
- Mortality:
- 2000 mg/kg bw: 5/5, days to death: 1, 1, 0, 1, 1;
1000 mg/kg bw: 4/5, days to death: 5, 5, 11, 1;
500 mg/kg bw. 3/5, days to death: 6, 4, 8;
252 mg/kg bw: 0/5 - Clinical signs:
- - sluggish
- body temperature was reduced
- one animal was narcotic. - Body weight:
- inconspicous
- Gross pathology:
- Findings in survivors:
- congestion of the lungs, liver and kidney
- hemorrhage of the stomach
- congestion, hemorrhage or opacity of the intestine - Other findings:
- The test substance caused dose and concentration dependent toxicity after a single ingestion.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- CLP: Acute Tox. 4, H302
After oral administration to rats, the test material diethylamine (CAS: 109-89-7) shows an LD50 of 540 mg/kg bw.
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