Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-196-7 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 403). Non GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no details on environmental conditions, no analytical data on the maximum attainable concentration.
- GLP compliance:
- no
- Remarks:
- not present at the time of performance.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction products of pentaerythritol, propoxylated and 1-chloro-2,3-epoxypropane with hydrogen sulfide
- EC Number:
- 701-196-7
- Cas Number:
- 72244-98-5
- Molecular formula:
- not applicable
- IUPAC Name:
- Reaction products of pentaerythritol, propoxylated and 1-chloro-2,3-epoxypropane with hydrogen sulfide
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): DION® Polymercaptan Resin DPM 3-800LC
- Description: viscous, amber liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino Charles River strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Age at study initiation: no data
- Weight at study initiation: 200 g (average)
- Housing: individually in stock cages
- Diet: free access to standard laboratory diet (Purina Rat Chow)
- Water: free access to water
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
No data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Vapor generator
- Exposure chamber volume: 70 L
- Method of holding animals in test chamber: Each animal was caged separately
- Source and rate of air: 4.0 L/min
- Temperature, humidity, pressure in air chamber: 26°C and the pressure was 29. 79 inches Hg
TEST ATMOSPHERE
- Brief description of analytical method used: no data
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- not specified
- Remarks:
- Average nominal vapor concentration was calculated by dividing the generator weight loss by the total volume of air used during the test.
- Duration of exposure:
- 4 h
- Concentrations:
- 0.1 mg/L (nominal), 99% of maximum vapor concentration was established.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Body weights were determined prior to inhalation exposure and for each surviving animal at the end of the 14-day observation period.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.1 mg/L air (nominal)
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: No data.
- Body weight:
- No adverse effects were observed (results not included).
- Gross pathology:
- No abnormalities were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to Regulation (EC) No 1272/2008
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute inhalation toxicity study with male and female rats, performed equivalent to OECD 403 guideline, an LC50 > 0.1 mg/L air was determined.
- Executive summary:
The test substance DPM 3 -800LC was tested in an acute inhalation toxicity study with male and female rats, performed equivalent to OECD 403 guideline. Concentration of 0.1 mg/L (nominal), 99% of maximum vapor concentration was established. No deaths occurred. At gross pathology no abnormalities were observed.
Based on the results, an LC50 > 0.1 mg/L air was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
