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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 March 2015 - 05 September 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
(1998)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
62.1 g/L
Temp.:
20 °C
pH:
3.5 - 3.6
Remarks on result:
other: Mean of the concentrations analysed at t=48 h and t=72 h.
Details on results:
The concentration analysed after 24, 48 and 72 hours of stirring was 79.5 g/L, 63.8 g/L and 60.4 g/L , resp. The maximum difference (MD) is >15% in this case (28.1%). Based on this, the water solubility of the test substance was given as the mean value of the 48- and 72-hour measurements, as the MD is ≤ 15% in this case (5.5%). No test substance was detected in the pretreated sample from the blank water mixture.

 

Stirring time

[hours]

Analysed concentration
[g/L]

Mean

[g/L]

MD

[%]

pH

24

79.5

3.5

48

63.8

62.1

5.5

3.6

72

60.4

3.6

 

Conclusions:
Interpretation of results: very soluble (> 10000 mg/L)
In a GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840 using the flask method, the water solubility of the substance at 20°C has been determined as 62.1 g/L. The pH of the saturated solution was 3.5-3.6.

Description of key information

The water solubility of the substance at 20 °C was determined to be 62.1 g/L.

Key value for chemical safety assessment

Water solubility:
62.1 g/L
at the temperature of:
20 °C

Additional information

Determined in a GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840 using the flask method.