Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Description of key information

No information is available on bioaccumulation and generation is not deemed necessary. GPM-800 is not expected to bioaccumulate significantly in aquatic organisms upon exposure and thus no bioaccumulation test is proposed.

Key value for chemical safety assessment

Additional information

The log Pow was estimated to be > 1.2 at 20 ºC based on the combined characteristics of moderate water solubility and moderate to high lipophilicity of GPM-800. Accumulation is per definition the net result of absorption (uptake), distribution, metabolism and excretion of a substance in an organism. Even though the substance has a very wide molecular weight range, the representative molecular weight was 800 g/mol. Molecules with such a high molecular weight often show steric hindrance of passage across cell membranes. In case absorption would occur, wide distribution of GPM-800 throughout the body is expected based on its water solubility and its molecular weight range. As GPM-800 dissolves both in water and in n-octanol, it is expected not to have a special preference for fatty tissues. GPM-800 is expected to be excreted via urine. Based on these considerations, GPM-800 is not expected to bioaccumulate significantly in aquatic organisms upon exposure and thus no bioaccumulation test is proposed.