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EC number: 209-674-2
CAS number: 590-19-2
1,2-Butadiene is a flammable gas at room temperature and therefore conventional skin and eye irritation studies cannot be carried out. Limited data on its isomer, 1,3-butadiene, indicates that 1,2-butadiene is not irritating to skin or eyes. Based on physical chemical properties, the liquid gas may cause burns and frostbite due to the extreme cold of the liquid.
accordance with REACH
Annexes VII and VIII column 2 adaptation,
studies on skin and eye irritation do not need to be conducted as the
substance is flammable in
No skin or eye irritation studies have been conducted with 1,2
there is no indication from other studies in animals that 1,2-butadiene
is irritating to the skin. In liquid form it may cause burns and
frostbite due to extreme cold..
data are available on the effect of its structural analogue
1,3-butadiene on the eye. Exposure of rabbits and dogs to 6,700ppm
(14,824 mg/m3) for 7.5 h/day for 6 days/week for 8 months had no effect
on the eyes (Carpenter et al, 1944). Humans exposed to 2000 ppm (4425
mg/m3) and 4000 ppm (8851 mg/m3) 1,3-butadiene
described slight smarting of the eyes and difficulty in focusing
although at 8000 ppm (17701 mg/m3) no subjective symptoms
were reported (Carpenter et al, 1944). The
available data therefore indicate that 1,2 -butadiene is not irritating
to skin or eyes.
-Butadiene is a flammable gas at room temperature and therefore
inhalation exposure is the only relevant route. 1,2 -Butadiene is
non-irritating and does not warrant classification under Dir 67/548/EEC
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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