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EC number: 209-674-2
CAS number: 590-19-2
1,2-Butadiene is a flammable gas at room temperature and therefore the requirement for data on acute oral and dermal toxicity is waived in accordance with REACH Annex XI. The acute inhalation LC50 of 1,2-butadiene in rats is greater than 8000 ppm (17,701 mg/m3) (the explosive limit).
requirement for data on acute oral and dermal toxicity is waived in
accordance with REACH Annex XI, as 1,2 -butadiene is a flammable gas at
The acute inhalation LC50 of 1,2-butadiene in rats was reported to be
greater than 0.8% (v/v) (8000 ppm,17,701 mg/m3). Higher
concentrations could not be tested because of the risk of explosion.
Exposure to 1,2 -butadiene resulted in narcosis but no mortality or
abnormal behaviour occurred in the post-exposure observation period (TNO
are no acute toxicity data on 1,2 -butadiene in humans but volunteer
studies have been carried out on 1,3 -butadiene in humans. Unsteadiness
was noted after exposure at 4000 ppm (8851 mg/m3) for 6 h and
the odour was described as objectionable, but there was little effect at
8000 ppm (17,701 mg/m3) for 8h (Carpenter et al, 1944). 1,2
-Butadiene is concluded to have low acute toxicity.
-Butadiene is a flammable gas at room temperature and therefore
inhalation exposure is the only relevant route. 1,2 -Butadiene is of low
acute toxicity by the inhalation route with LC50 values exceeding the
doses which would warrant classification under Dir 67/548/EEC or GHS/CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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