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EC number: 252-046-8
CAS number: 34455-29-3
28-day repeated oral administration toxicity test and was carried in
male and female rats at doses of 0, 10, 40, 200, or 1000 mg/kg/day. A
14-day recovery period was included at 0 and 1000 mg/kg/day.
mortality attributable to the test substance was observed. There
were no toxicological effects of test substance administration with
respect to haematology, clinical chemistry, urinalysis, or gross
pathology. Males and females at ≥200 mg/kg had soft stool, which was
considered to be test substance related. In addition, males at 1000
mg/kg had reduced body weights from day 12 to day 28. Increased relative
liver weight was observed in females at 1000 mg/kg. Centrilobular
hepatic cell hypertrophy and single cell necrosis in the liver were
observed in males at 1000 mg/kg. In the recovery test, all changes
observed during the administration term and at the end of the
administration terms showed recovery. The results as described above
suggested test substance-related effects of soft stool, decreases in
bodyweight, and liver changes, which were all considered reversible. The
NOEL under the conditions of this study was 40 mg/kg/day based on the
observation of soft stool in males and females at doses of ≥200
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