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EC number: 252-046-8
CAS number: 34455-29-3
single dose of the test item was applied to the shaved, intact skin of 5
male and 5 female rats at a dose level of 5000 mg/kg of body weight. The
application site was covered with a semi-occlusive dressing for 24
hours, after which the test substance was removed. The rats were
observed for 14 days following application. The rats were necropsied to
detect grossly observable evidence of organ or tissue damage at the end
of the 15-day test period.
were no incidents of mortality, no overall body weight losses, and no
clinical abnormalities or other signs of skin irritation observed during
the study. No gross lesions were present in the rats at necropsy. Under
the conditions of this study, the dermal LD50 for the test
item was greater than 5000 mg/kg of body weight when applied to the skin
of male and female rats for 24 hours.
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