Registration Dossier

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation, other
Remarks:
in vivo study
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Only results given (methodical details are missing)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984
Report Date:
1984

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Several crystals of the compound were placed into the conjunctival sac of 6 rabbit eyes (3 rinsed/not rinsed each)
GLP compliance:
no
Remarks:
Data from 1980 (at this time GLP was not compulsory)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
not further specified

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
not further specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
several crystals (not further specified)
Duration of treatment / exposure:
not further specified
Observation period (in vivo):
not further specified
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Results
Irritation parameter:
other: The treatment caused only slight eye irritation in all animals.
Remarks on result:
probability of weak irritation
Irritant / corrosive response data:
The treatment caused only slight eye irritation in all animals.

Any other information on results incl. tables

The treatment caused only slight eye irritation in all animals.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The application of several crystals of benzophenone into the conjunctival sac of rabbits caused only a slight reaction.
Executive summary:

In this study with rabbits the application of several crystals of benzophenone into the conjunctival sac (3 rinsed/not rinsed each) caused only a slight reaction. Thus benzophenone is not subject of classification.