Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Only results given (methodical details missing)

Data source

Reference
Reference Type:
publication
Title:
Monographs on fragrance raw materials: Benzophenone
Author:
Opdyke DLJ
Year:
1979
Bibliographic source:
Food Cosmet Toxicol 11, 873-874

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method not further specied
GLP compliance:
no
Test type:
other: not further specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Benzophenone

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not further specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
not further specified
Duration of exposure:
not further specified
Doses:
not further specified
No. of animals per sex per dose:
not further specified
Control animals:
not specified
Details on study design:
not further specified
Statistics:
not further specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 535 mg/kg bw
Based on:
test mat.
95% CL:
>= 2 007 - <= 6 226
Mortality:
not further specified
Clinical signs:
not further specified
Body weight:
not further specified
Gross pathology:
not further specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute dermal toxicity (LD50) in rabbits was reported to be at 3535 mg/kg bw.
Executive summary:

In this review the dermal LD50 value for benzophenone in rabbits was given with 3535 mg/kg bw. Thus benzophenone is practically non-toxic in the rabbit after a single dermal dose and is thus not subject of classification.