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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Some methodical details are missing

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of photosensitizer agents and photodegadable polyolefins
Author:
Caprino L, Togna G & Mazzei M
Year:
1975
Bibliographic source:
Eur J Toxicol Environ Hyg 9, 99-103

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not applicable
Principles of method if other than guideline:
The study was performed using 8 animals per group with 5 dose groups. The post-observation period was 7 days.
GLP compliance:
no
Remarks:
Study from 1975 (at this time GLP was not compulsory)
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
Swiss
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 19-25 g
- Fasting period before study: 16 hours

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: gum arabicum
Details on oral exposure:
no further data
Doses:
no data
No. of animals per sex per dose:
8 animals per dose
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Statistics:
Probit analysis with confidence limits

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 895 mg/kg bw
Based on:
test mat.
95% CL:
>= 2 441 - <= 3 434
Mortality:
not further specified
Clinical signs:
In lethal doses, benzophenone induced sedation, progressive depression of motor activity, unstable gait, tremors and respiratory impairment.
Body weight:
not further specified
Gross pathology:
No gross lesions detected at necropsy

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute oral toxicity in mice (LD50) was 2895 mg/kg bw
Executive summary:

Benzophenone was administered by oral gavage as single application to Swiss mice to determine the acute toxicity. A necropsy was performed 7 days after administartion of the test item. Clinical signs at lethal doses were sedation, progressive depression of motor activity, unstable gait, tremors and respiratory impairment.

The acute oral toxicity in mice was determined by Probit analysis at 2895 mg/kg bw.