Registration Dossier
Registration Dossier
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EC number: 415-510-2 | CAS number: 145703-76-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance has a low potential for absorption via oral, dermal and respiratory routes.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
According to the Annex VIII of the REACH Regulation (EC 1907/2006), the assessment of the toxicokinetics behaviour of the substance should be done to the extent that can be derived from the relevant available information.
Based on the physicochemical properties of the substance (mainly physical state and particle size, chemical structure and functional groups, molecular weight, water solubility, octanol/water partition coefficient), the potential of absorption is expected to be low. In particular, hydrophilicity and water solubility of the substance are expected to limit its potential for accumulation and to control its distribution and excretion.
Once entered the body, enzymatic reactions typically degrade the molecule, leading to metabolites with higher solubility that are more rapidly excreted.
Azo bonds within the molecule are susceptible to metabolic transformations, leading to bond cleavage by a reductive process. Sulfonation of azo molecules increase stability and decrease toxicity of the molecule itself and of its metabolites by enhancing urinary excretion. Azo compound or its metabolites may also undergo microsomal oxidation, N-acetylation or O-esterification.Available toxicological studies by oral route, i.e. acute toxicity, repeated dose toxicity and reproductive toxicity, did not evidenced systemic effects, thus suggesting poor absorption and/or low toxicity of the substance and its metabolites. Similarly, in available studies by dermal route, i.e. acute toxicity, skin irritation and skin sensitisation, no systemic effects were seen, thus indicating low absorption rate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
